DNA Testing for Smart Life Choices

Overweight Potential

An inactive lifestyle and poor diet are the main causes of excessive weight gain, but genetic makeup is also a strong determining factor. This is something most people don’t understand about themselves, yet it is vitally important. Understanding how your DNA influences your weight can help you maintain an ideal weight or lose the weight you need to be healthy.

Metabolism can be changed, to some degree, through diet and exercise, but your genes cannot be changed. Your natural tendency to gain weight as well as where on your body you accumulate fat reserves is embedded in your genes. You can understand the genetic potential of your body to gain and store excess weight.

Make better lifestyle choices by learning more about your DNA. Take the Overweight Potential DNA Test today to find out!

Genetics 101

Every cell in the human body contains DNA– a long complex chain made of billions of bases called nucleotides. Only four types of nucleotides compose the DNA chain: These are A=Adenine G = Guanin, T=Thymine, C= Cytosine. The DNA chain is packed in 23 separate packages called chromosomes, which make our genome. A gene is a sequence of hundreds, thousands or even tens of thousands of nucleotides. Human cells have two copies for almost every gene in our genome. Together, all of our genes determine our physical characteristics and traits.

Nucleotide sequence in the DNA chain has some differences for each person, which is what makes each of us unique. A change in the sequence of even a single nucleotide can determine a person’s certain tendency. Studies have found that is it enough for a person to have a change in a single nucleotide (known as SNP-Single Nucleotide Polymorphism) to mark a gene and to be able to predict with certainty that this person has a specific tendency.
(read more about DNA and genes in Genetics 101).

Overweight Potential Test
Since excess weight gain is a systemic physical condition, its markers are evaluated in regard to some indices or physical attributes. Those that are referred to in our Overweight Potential Test are:

-  Body weight – This factor is measured in pounds (or kilograms). Whether or not you are overweight is determined by age, gender and height; these are the prime indicating factors for excess weight gain and storage. Body weight is comprised of muscle, bone, fat and water and fat accumulation is like the body’s warehouse, if it is unable to use energy from calories that it receives from food, it stores them for a later date. Excess weight gain occurs slowly overtime, as the human body ages, but also when you eat more calories than you use.

-  Waist circumference – This factor is measured in inches (or centimeters). A large waist circumference, which is indicative of excessive fat accumulation in the abdominal region is known to be linked with some severe medical conditions.

-  Body Mass Index (BMI) – Body mass index (BMI) is a measurement which compares weight and height. Your BMI can define if you are overweight or have the capacity to be excessively overweight. If your BMI is between 25 kg/m2 and 30 kg/m2, you are considered overweight. When it is greater than 30 kg/m2, you are considered at risk for being excessively overweight.

BMI is a numeric value determined by dividing the body weight by the square root of the height:
- Metric: BMI = kilograms / meters2
- US customary and Imperial System: BMI = lb * 703 / in2

Our test is compromised of several selected markers from the FTO (rs9939609), PCSK1 (rs6232) and TMEM18 (rs6548238) genes. These Genes and their associated markers were selected based on current research findings with a high statistical significance.

These testimonials are based on fictional accounts, but for most of us, they are all-too familiar situations.

"By the time my brother turned 30, he already weighed 300 lbs.! My mother is over 340 lbs. for so many years, and my grandmother would never even tell us her weight. My boyfriend always warned me that when I reached 30, I would become just like them. After taking the Overweight Potential Test, I was finally able to show him that I had my father's genes. My boyfriend immediately proposed to me. But I haven't decided yet J…"

"I'm a 15-year old computer geek. Kids have been laughing at me for years, for being the fattest kid in the class. For two years, I've begged to my parents to take me to a dietician, but all they said was "Nothing can be done; because of our family's genes you are doomed to be fat." One day, my cousin referred me to The makingsofme web site, I decided to ask for the Overweight Potential Test for my 16th birthday and all I have to say is thank you! This gift has changed my life! When the results came back to me, it was evident. My excess weight gain markers turned out to be as those of thin people. My mother immediately realized that I actually always had the potential to lose weight and live a happier and healthier life. She set an appointment with a dietician soon after and since then, I have lost 30 pounds! As a result, I play outside more, joined a baseball team and started making new friends. Most importantly, I have more self-confidence, because I don’t get teased anymore.”

“My husband and I both have had issues with being overweight and our relatives are no different. We are thinking about having a baby and want to know the true genetic makeup of our bodies, so that we can prepare and make changes to our lives so that our future child will not overweight. We know that the Overweight Potential Test will help us resolve our questions.”


Results available online


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